SYSTEMIC LUPUS ERYTHEMATOSUS: IMMUNOPATHOGENESIS AND NOVEL THERAPEUTIC TARGETS

被引：10

作者：

Beccastrini, E. ^{[1
,2
]}

D'Elios, M. M. ^{[1
,2
,3
]}

Emmi, G. ^{[3
]}

Silvestri, E. ^{[1
,2
,3
]}

Squatrito, D. ^{[1
,2
,3
]}

Prisco, D. ^{[1
,2
,3
]}

Emmi, L. ^{[1
,2
]}

机构：

[1] AOU Careggi, SOD Patol Med, Ctr Autoimmune Syst Dis, Behcet Ctr, I-50134 Florence, Italy

[2] AOU Careggi, Lupus Clin, I-50134 Florence, Italy

[3] Univ Florence, Dept Expt & Clin Med, I-50121 Florence, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2013年 / 26卷 / 03期

关键词：

systemic lupus erythematosus; SLE pathogenesis; biologic therapies; belimumab; auto immune diseases; autoantibodies; DNA METHYLATION; CELLS; PATHOGENESIS; IDENTIFICATION; MECHANISMS; NEPHRITIS; DISEASE;

D O I：

10.1177/039463201302600302

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.

引用

页码：585 / 596

页数：12

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