Successive Mechanochemical Activation and Small Molecule Release in an Elastomeric Material

被引：128

作者：

Larsen, Michael B. ^{[1
]}

Boydston, Andrew J. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 04期

关键词：

CONTROLLED DRUG-DELIVERY; STRESS-STRAIN BEHAVIOR; POLYMERS; SYSTEMS;

D O I：

10.1021/ja411891x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a mechanochemically responsive material capable of successively releasing small organic molecules from a cross-linked network upon repeated compressions. The use of a flex activated mechanophore that does not lead to main chain scission and an elastomeric polyurethane enabled consecutive compressions with incremental increases in the % mechanophore activation. Additionally, we examined the effect of multiple applications of compressive stress on both mechanophore activity and the mechanical behavior of the elastomeric matrix in which the mechanophore is embedded.

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页码：1276 / 1279

页数：4

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