Treatment of aggressive non-Hodgkin's lymphomas

被引：0

作者：

Moreno Nogueira, J. A. ^{[1
]}

Ruiz Borrego, M. ^{[1
]}

Perez Valderrama, B. ^{[1
]}

Valero Azbiru, M. ^{[2
]}

机构：

[1] Hosp Univ Virgen Rocio, Med Oncol Serv, Seville, Spain

[2] Hosp Infanta Luisa, Seville, Spain

来源：

REVISTA CLINICA ESPANOLA | 2009年 / 209卷 / 02期

关键词：

3-WEEKLY CHOP CHEMOTHERAPY; B-CELL LYMPHOMA; ELDERLY-PATIENTS; TRIAL; RITUXIMAB; ETOPOSIDE; THERAPY; DSHNHL;

D O I：

10.1016/S0014-2565(09)70632-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aggressive non-Hodgkin's lymphomas (NHL) in localized stages I and II, without bulky areas and a fair International Prognostic Factor (IPI) (30% of all cases) have high possibilities of cure (80%) when treated with combined chemotherapy, CHOP or CHOP-like (3-4 courses) followed by locoregional radiation therapy. Localized aggressive non-Hodgkin's lymphomas with signs of poor prognosis or advanced stages (III and IV) must be treated with rituximab-containing immunochemotherapy. As second line in responding patients (DHAP, ESHAP, MINE, VIM, DICE, etc., and rituximab) high doses chemotherapy with hematopoietic growth factor support should be considered, although not in refractory patients. (C) 2008 Elsevier Espana, S.L. All rights reserved.

引用

页码：88 / 92

页数：5

共 18 条

[1] Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach [J].

Abramson, JS ;

Shipp, MA .

BLOOD, 2005, 106 (04) :1164-1174

[2] Sequential high dose chemotherapy as initial treatment for aggressive sub-types of Non-Hodgkin Lymphoma: results of the international randomized phase III trial (MISTRAL) [J].

Betticher, D. C. ;

Martinelli, G. ;

Radford, J. A. ;

Kaufmann, M. ;

Dyer, M. J. S. ;

Kaiser, U. ;

Aulitzky, W. E. ;

Beck, J. ;

von Rohr, A. ;

Kovascovics, T. ;

Cogliatti, S. B. ;

Cina, S. ;

Maibach, R. ;

Cerny, T. ;

Linch, D. C. .

ANNALS OF ONCOLOGY, 2006, 17 (10) :1546-1552

[3]

Blay JY, 1998, BLOOD, V92, P3562

[4] CHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients:: A study by the Groupe d'Etude des Lymphomes de I'Adulte [J].

Bonnet, Christophe ;

Fillet, Georges ;

Mounier, Nicolas ;

Ganem, Gard ;

Molina, Thierry Jo ;

Thieblemont, Catherine ;

Ferme, Christophe ;

Quesnel, Bruno ;

Martin, Claude ;

Gisselbrecht, Christian ;

Tilly, Herve ;

Reyes, Felix .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (07) :787-792

[5]

COIFFIER B, 2007, ASCO 1 S, V18, P8009

[6] Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma [J].

Habermann, Thomas M. ;

Weller, Edie A. ;

Morrison, Vicki A. ;

Gascoyne, Randy D. ;

Cassileth, Peter A. ;

Cohn, Jeffrey B. ;

Dakhil, Shaker R. ;

Woda, Bruce ;

Fisher, Richard I. ;

Peterson, Bruce A. ;

Horning, Sandra J. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (19) :3121-3127

[7]

HAIOUN C, 2007, ASCO, V8012

[8]

JONG D, 2007, J CLIN ONCOL, V25, P805

[9] Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin's lymphomas [J].

Khouri, IF ;

Saliba, RM ;

Hosing, C ;

Okoroji, GJ ;

Acholonu, S ;

Anderlini, P ;

Couriel, D ;

De Lima, M ;

Donato, ML ;

Fayad, L ;

Giralt, S ;

Jones, R ;

Korbling, M ;

Maadani, F ;

Manning, JT ;

Pro, B ;

Shpall, E ;

Younes, A ;

McLaughlin, P ;

Champlin, RE .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (10) :2240-2247

[10] Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma:: Results of a prospective randomized trial of the German low grade lymphoma study group (GLSG) [J].

Lenz, G ;

Dreyling, M ;

Hoster, E ;

Wörmann, B ;

Dührsen, U ;

Metzner, B ;

Eimermacher, H ;

Neubauer, A ;

Wandt, H ;

Steinhauer, H ;

Martin, S ;

Heidemann, E ;

Aldaoud, A ;

Parwaresch, R ;

Hasford, J ;

Unterhalt, M ;

Hiddemann, W .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (09) :1984-1992

← 1 2 →