Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma

被引：20

作者：

Abeykoon, Jithma P. ^{[1
]}

Murray, David L. ^{[2
]}

Murray, Isaiah ^{[2
]}

Jevremovic, Dragan ^{[2
]}

Otteson, Gregory E. ^{[2
]}

Dispenzieri, Angela ^{[1
]}

Arendt, Bonnie K. ^{[2
]}

Dasari, Surendra ^{[3
]}

Gertz, Morie ^{[1
]}

Gonsalves, Wilson I. ^{[1
]}

Kourelis, Taxiarchis V. ^{[1
]}

Muchtar, Eli ^{[1
]}

Dingli, David ^{[1
]}

Warsame, Rahma ^{[1
]}

Go, Ronald S. ^{[1
]}

Lacy, Martha Q. ^{[1
]}

Leung, Nelson ^{[1
]}

Buadi, Francis ^{[1
]}

Lin, Yi ^{[1
]}

Kyle, Robert A. ^{[1
]}

Rajkumar, Vincent ^{[1
]}

Kumar, Shaji ^{[1
]}

Kapoor, Prashant ^{[1
]}

机构：

[1] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA

[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[3] Mayo Clin, Dept Hlth Sci & Res, Rochester, MN USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 193卷 / 02期

关键词：

mass spectroscopy; measurable residual disease; prognosis; MINIMAL RESIDUAL DISEASE; FLOW-CYTOMETRY; SPECTROMETRY; SURVIVAL;

D O I：

10.1111/bjh.17195

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Measurable residual disease (MRD) assessment by marrow-based next-generation flow cytometry (NGF) following autologous stem cell transplantation (ASCT) may lead to false-negative results due to patchy marrow involvement and extramedullary disease in patients with multiple myeloma. We assessed the value of simultaneous MRD evaluation with NGF and serum matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MASS-FIX). Of all 61 complete responders who were NGF-negative for MRD, around day-100 post ASCT, 59% were MASS-FIX-positive. At median follow-up of 26 months, 69% of MASS-FIX(+)/NGF(-) patients were alive and progression-free versus 96% of MASS-FIX(-)/NGF(-) patients, P = 0 center dot 02. MASS-FIX, a simple peripheral blood-based assay complements marrow-based NGF to accurately prognosticate patients with myeloma.

引用

页码：380 / 385

页数：6

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