Epigenetic Regulation of HIV-1 Latency in Astrocytes

被引：74

作者：

Narasipura, Srinivas D. ^{[1
]}

Kim, Stephanie ^{[1
]}

Al-Harthi, Lena ^{[1
]}

机构：

[1] Rush Univ, Med Ctr, Dept Immunol Microbiol, Chicago, IL 60612 USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 05期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; CD4(+) T-CELLS; HISTONE DEACETYLASE INHIBITORS; NECROSIS-FACTOR-ALPHA; FETAL GLIAL-CELLS; INFECTED INDIVIDUALS; GAMMA-INTERFERON; GENE-EXPRESSION; PLASMA VIREMIA;

D O I：

10.1128/JVI.03333-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and macrophages. Because astrocytes are the most abundant cell type in the brain, we evaluated epigenetic regulation of HIV latency in astrocytes. We have shown that class I histone deacetylases (HDACs) and a lysine-specific histone methyltransferase, SU(VAR)3-9, play a significant role in silencing of HIV transcription in astrocytes. Our studies add to a growing body of evidence demonstrating that astrocytes are a reservoir for HIV.

引用

页码：3031 / 3038

页数：8

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