MAP'ing CNS Development and Cognition: An ERKsome Process

被引：158

作者：

Samuels, Ivy S. ^{[1
,2
,3
]}

Saitta, Sulagna C. ^{[4
]}

Landreth, Gary E. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

[2] Cole Eye Inst, Dept Ophthalm Res, Cleveland, OH 44195 USA

[3] Louis Stokes Cleveland VA Med Ctr, Cleveland, OH 44106 USA

[4] Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

来源：

NEURON | 2009年 / 61卷 / 02期

关键词：

ACTIVATED PROTEIN-KINASE; 22Q11.2 DELETION SYNDROME; FIBROBLAST-GROWTH-FACTOR; HIPPOCAMPAL VOLUME REDUCTION; OF-FUNCTION MUTATIONS; NOONAN-SYNDROME; SIGNAL-TRANSDUCTION; DIGEORGE-SYNDROME; IN-VIVO; CORTICAL NEUROGENESIS;

D O I：

10.1016/j.neuron.2009.01.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.

引用

页码：160 / 167

页数：8

共 78 条

[31] The spread of Ras activity triggered by activation of a single dendritic spine [J].

Harvey, Christopher D. ;

Yasuda, Ryohei ;

Zhong, Haining ;

Svoboda, Karel .

SCIENCE, 2008, 321 (5885) :136-140

[32] Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and ras-dependent mechanisms [J].

Hegedus, Balazs ;

Dasgupta, Biplab ;

Shin, Jung Eun ;

Emnett, Ryan J. ;

Hart-Mahon, Elizabeth K. ;

Elghazi, Lynda ;

Bernal-Mizrachi, Ernesto ;

Gutmann, David H. .

CELL STEM CELL, 2007, 1 (04) :443-457

[33] FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development [J].

Inglis-Broadgate, SL ;

Thomson, RE ;

Pellicano, F ;

Tartaglia, MA ;

Pontikis, CC ;

Cooper, JD ;

Iwata, T .

DEVELOPMENTAL BIOLOGY, 2005, 279 (01) :73-85

[34] Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse [J].

Kawauchi, S ;

Shou, JY ;

Santos, R ;

Hébert, JM ;

McConnell, SK ;

Mason, I ;

Calof, AL .

DEVELOPMENT, 2005, 132 (23) :5211-5223

[35] Recurrent 16p11.2 microdeletions in autism [J].

Kumar, Ravinesh A. ;

KaraMohamed, Samer ;

Sudi, Jyotsna ;

Conrad, Donald F. ;

Brune, Camille ;

Badner, Judith A. ;

Gilliam, T. Conrad ;

Nowak, Norma J. ;

Cook, Edwin H., Jr. ;

Dobyns, William B. ;

Christian, Susan L. .

HUMAN MOLECULAR GENETICS, 2008, 17 (04) :628-638

[36] Psychological profile of children with Noonan syndrome [J].

Lee, DA ;

Portnoy, S ;

Hill, P ;

Gillberg, C ;

Patton, MA .

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2005, 47 (01) :35-38

[37]

Leppig KA, 1997, AM J MED GENET, V73, P197, DOI 10.1002/(SICI)1096-8628(1997)73:2<197::AID-AJMG17>3.0.CO

[38]

2-P

[39] Chromosomal microdeletions:: Dissecting del22q11 syndrome [J].

Lindsay, EA .

NATURE REVIEWS GENETICS, 2001, 2 (11) :858-868

[40] A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo [J].

Lunn, J. Simon ;

Fishwick, Katherine J. ;

Halley, Pam A. ;

Storey, Kate G. .

DEVELOPMENTAL BIOLOGY, 2007, 302 (02) :536-552

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