MAP'ing CNS Development and Cognition: An ERKsome Process

被引：158

作者：

Samuels, Ivy S. ^{[1
,2
,3
]}

Saitta, Sulagna C. ^{[4
]}

Landreth, Gary E. ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

[2] Cole Eye Inst, Dept Ophthalm Res, Cleveland, OH 44195 USA

[3] Louis Stokes Cleveland VA Med Ctr, Cleveland, OH 44106 USA

[4] Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

来源：

NEURON | 2009年 / 61卷 / 02期

关键词：

ACTIVATED PROTEIN-KINASE; 22Q11.2 DELETION SYNDROME; FIBROBLAST-GROWTH-FACTOR; HIPPOCAMPAL VOLUME REDUCTION; OF-FUNCTION MUTATIONS; NOONAN-SYNDROME; SIGNAL-TRANSDUCTION; DIGEORGE-SYNDROME; IN-VIVO; CORTICAL NEUROGENESIS;

D O I：

10.1016/j.neuron.2009.01.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.

引用

页码：160 / 167

页数：8

共 78 条

[1] 22q11.2 Deletion Syndrome: Genetics, neuroanatomy and cognitive/behavioral features [J].

Antshel, KM ;

Kates, WR ;

Roizen, N ;

Fremont, W ;

Shprintzen, RJ .

CHILD NEUROPSYCHOLOGY, 2005, 11 (01) :5-19

[2] The RAS/MAPK syndromes: Novel roles of the RAS pathway in human genetic disorders [J].

Aoki, Yoko ;

Niihori, Tetsuya ;

Narumi, Yoko ;

Kure, Shigeo ;

Matsubara, Yoichi .

HUMAN MUTATION, 2008, 29 (08) :992-1006

[3] Role of MAPKs in development and differentiation: lessons from knockout mice [J].

Aouadi, M. ;

Binetruy, B. ;

Caron, L. ;

Le Marchand-Brustel, Y. ;

Bost, F. .

BIOCHIMIE, 2006, 88 (09) :1091-1098

[4] Discovery of a previously unrecognized microdeletion syndrome of 16p11.2-p12.2 [J].

Ballif, Blake C. ;

Hornor, Sara A. ;

Jenkins, Elizabeth ;

Madan-Khetarpal, Suneeta ;

Surti, Urvashi ;

Jackson, Kelly E. ;

Asamoah, Alexander ;

Brock, Pamela L. ;

Gowans, Gordon C. ;

Conway, Robert L. ;

Graham, John M., Jr. ;

Medne, Livija ;

Zackai, Elaine H. ;

Shaikh, Tamim H. ;

Geoghegan, Joel ;

Selzer, Rebecca R. ;

Eis, Peggy S. ;

Bejjani, Bassem A. ;

Shaffer, Lisa G. .

NATURE GENETICS, 2007, 39 (09) :1071-1073

[5] 22q11.2 distal deletion: A recurrent genomic disorder distinct from DiGeorge syndrome and velocardiofacial syndrome [J].

Ben-Shachar, Shay ;

Ou, Zhishuo ;

Shaw, Chad A. ;

Belmont, John W. ;

Patel, Millan S. ;

Hummel, Marybeth ;

Amato, Stephen ;

Tartaglia, Nicole ;

Berg, Jonathan ;

Sutton, V. Reid ;

Lalani, Seema R. ;

Chinault, A. Craig ;

Cheung, Sau W. ;

Lupski, James R. ;

Patel, Ankita .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (01) :214-221

[6] Stops along the RAS pathway in human genetic disease [J].

Bentires-Alj, M ;

Kontaridis, MI ;

Neel, BG .

NATURE MEDICINE, 2006, 12 (03) :283-285

[7] Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype [J].

Brems, Hilde ;

Chmara, Magdalena ;

Sahbatou, Mourad ;

Denayer, Ellen ;

Taniguchi, Koji ;

Kato, Reiko ;

Somers, Riet ;

Messiaen, Ludwine ;

De Schepper, Sofie ;

Fryns, Jean-Pierre ;

Cools, Jan ;

Marynen, Peter ;

Thomas, Gilles ;

Yoshimura, Akihiko ;

Legius, Eric .

NATURE GENETICS, 2007, 39 (09) :1120-1126

[8] The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum [J].

Chi, CL ;

Martinez, S ;

Wurst, W ;

Martin, GR .

DEVELOPMENT, 2003, 130 (12) :2633-2644

[9]

Christen B, 1999, DEVELOPMENT, V126, P119

[10] Spatial and temporal patterns of ERK signaling during mouse embryogenesis [J].

Corson, LB ;

Yamanaka, Y ;

Lai, KMV ;

Rossant, J .

DEVELOPMENT, 2003, 130 (19) :4527-4537

← 1 2 3 4 5 6 7 8 →