CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy

被引：105

作者：

Han, Qiusen ^{[1
,2
]}

Wang, Xinhuan ^{[1
]}

Jia, Xinghang ^{[1
]}

Cai, Shuangfei ^{[1
]}

Liang, Wei ^{[3
]}

Qin, Yan ^{[3
]}

Yang, Rong ^{[1
,2
]}

Wang, Chen ^{[1
,2
]}

机构：

[1] Univ Chinese Acad Sci Beijing, Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Sinodanish Ctr Educ & Res, Sinodanish Coll, Beijing 100190, Peoples R China

[3] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

来源：

NANOSCALE | 2017年 / 9卷 / 18期

基金：

中国国家自然科学基金;

关键词：

GRAPHENE OXIDE; DRUG-DELIVERY; THERAPY; NANOPARTICLES; NANOTUBES; EVOLUTION; ADJUVANT;

D O I：

10.1039/c7nr01460k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single or few-layered MoS2 nanosheets, as a novel class of 2D nanomaterials, have received tremendous attention due to their fantastic physical and chemical properties. Here, we fabricated MoS2-PEG-CpG with a small and uniform size as a multifunctional platform for photothermal enhanced immunotherapy. MoS2 nanosheets were fabricated by chemical exfoliation and further probe sonication. To realize MoS2-based adjuvant delivery, MoS2 nanosheets were functionalized with cytosine-phosphate-guanine (CpG) and polyethylene glycol (PEG) to form MoS2-PEG-CpG nanoconjugates. As an efficient nanocarrier with excellent near infrared-light (NIR) absorbing performance, MoS2-PEG-CpG significantly promotes CpG intracellular accumulation and the effect can be further enhanced by photothermal treatment. In addition, the enhanced uptake can stimulate the production of proinflammatory cytokines and remarkably elevate the immune response level. Finally, we found that MoS2-PEG-CpG could reduce the proliferative activity of cancer cells when co-cultured with a macrophage-like cell upon NIR irradiation, implying a novel strategy for multifunctional therapeutics against cancers.

引用

页码：5927 / 5934

页数：8

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