Effect of angiotensin-converting enzyme inhibition on Na+/H+-exchange and Ca2+-efflux in human erythrocytes

被引：0
|
作者：
Lijnen, P [1 ]
Arabidze, CG [1 ]
Petrov, V [1 ]
机构：
[1] CARDIOL RES CTR, MOSCOW 121552, RUSSIA
来源：
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 1997年 / 19卷 / 02期
关键词：
Na+/H+-exchange; Ca2+-efflux; ACE inhibition; captopril;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of the angiotensin-converting enzyme inhibitor, captopril, on Na+/H+-exchange activity and on Ca2+-ATPase mediated Ca2+-efflux was investigated in red blood cell membranes of patients with essential hypertension. The erythrocyte Na+/H+-exchange rate was measured as the difference in H+-efflux rate when measured in the presence or absence of Na+. The erythrocyte Ca2+-transport. mediated by Ca2+-ATPase was assayed as the erythrocyte Ca2+-efflux rate. Our data show that captopril, in vitro and in vivo, inhibits the Ca2+-ATPase mediated Ca2+-efflux rate in human erythrocytes, while in vivo it stimulates the erythrocytes Na+/H+-exchange rate.
引用
收藏
页码：125 / 128
页数：4
相关论文
共 50 条
  • [31] The effect of angiotensin-converting enzyme inhibition on inflammatory and angiogenic factors in hypercholesterolemia
    Maryam Mahmoudabady
    Narges Kazemi
    Saeed Niazmand
    Seyyed Abdolrahim Rezaee
    Mohammad Soukhtanloo
    Mahmoud Hosseini
    Pharmacological Reports, 2015, 67 : 837 - 841
  • [32] Possible effect of angiotensin-converting enzyme inhibition an glomerular charge selectivity
    Hansen, PM
    Mathiesen, ER
    KofoedEnevoldsen, A
    Deckert, T
    JOURNAL OF DIABETES AND ITS COMPLICATIONS, 1995, 9 (03) : 158 - 162
  • [33] The effect of angiotensin-converting enzyme inhibition on progression of aortic sclerosis and mortality
    Ardehali, Reza
    Leeper, Nicholas J.
    Heidenreich, Paul A.
    CIRCULATION, 2006, 114 (18) : 657 - 657
  • [34] The effect of angiotensin-converting enzyme inhibition on inflammatory and angiogenic factors in hypercholesterolemia
    Mahmoudabady, Maryam
    Kazemi, Narges
    Niazmand, Saeed
    Rezaee, Seyyed Abdolrahim
    Soukhtanloo, Mohammad
    Hosseini, Mahmoud
    PHARMACOLOGICAL REPORTS, 2015, 67 (05) : 837 - 841
  • [35] The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress
    Scribner, AW
    Loscalzo, J
    Napoli, C
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 482 (1-3) : 95 - 99
  • [36] Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade
    P Dandona
    S Dhindsa
    H Ghanim
    A Chaudhuri
    Journal of Human Hypertension, 2007, 21 : 20 - 27
  • [37] Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade
    Dandona, P.
    Dhindsa, S.
    Ghanim, H.
    Chaudhuri, A.
    JOURNAL OF HUMAN HYPERTENSION, 2007, 21 (01) : 20 - 27
  • [38] ANGIOTENSIN-CONVERTING ENZYME-INHIBITION AND NA APPETITE - MICROBEHAVIORAL ANALYSIS AND NYCTHEMERAL PHYSIOLOGY
    ROWLAND, NE
    NICHOLSON, TM
    SMITH, JC
    AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (01): : R7 - R13
  • [39] Angiotensin-converting enzyme 2 in human plasma and lung tissue
    Xie, Jing
    Huang, Qi-Fang
    Zhang, Zhihan
    Dong, Yihan
    Xu, Haimin
    Cao, Yanan
    Sheng, Chang-Sheng
    Li, Yan
    Wang, Chaofu
    Wang, Xuefeng
    Wang, Ji-Guang
    BLOOD PRESSURE, 2023, 32 (01) : 6 - 15
  • [40] CORRELATION BETWEEN CHANGES IN NA+/H+-EXCHANGE AND CYTOPLASMIC CA CONCENTRATION DURING PLATELET ACTIVATION
    BORIN, ML
    PINELIS, VG
    BYKOV, SS
    KUDINOV, YV
    AZIZOVA, OA
    VLADIMIROV, YA
    KHODOROV, BI
    MARKOV, KM
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1988, 106 (09) : 1263 - 1266
12345