Effect of angiotensin-converting enzyme inhibition on Na+/H+-exchange and Ca2+-efflux in human erythrocytes

被引：0
|
作者：
Lijnen, P [1 ]
Arabidze, CG [1 ]
Petrov, V [1 ]
机构：
[1] CARDIOL RES CTR, MOSCOW 121552, RUSSIA
来源：
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 1997年 / 19卷 / 02期
关键词：
Na+/H+-exchange; Ca2+-efflux; ACE inhibition; captopril;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of the angiotensin-converting enzyme inhibitor, captopril, on Na+/H+-exchange activity and on Ca2+-ATPase mediated Ca2+-efflux was investigated in red blood cell membranes of patients with essential hypertension. The erythrocyte Na+/H+-exchange rate was measured as the difference in H+-efflux rate when measured in the presence or absence of Na+. The erythrocyte Ca2+-transport. mediated by Ca2+-ATPase was assayed as the erythrocyte Ca2+-efflux rate. Our data show that captopril, in vitro and in vivo, inhibits the Ca2+-ATPase mediated Ca2+-efflux rate in human erythrocytes, while in vivo it stimulates the erythrocytes Na+/H+-exchange rate.
引用
收藏
页码：125 / 128
页数：4
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