RISC assembly: Coordination between small RNAs and Argonaute proteins

被引:235
作者
Kobayashi, Hotaka [1 ]
Tomari, Yukihide [1 ,2 ]
机构
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[2] Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Tokyo 1130032, Japan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2016年 / 1859卷 / 01期
关键词
RNA silencing; Small RNAs; RISC; Argonaute; Chaperone; siRNA; miRNA; piRNA; PRIMARY PIRNA BIOGENESIS; PIWI-INTERACTING RNAS; MICRORNA-DEPENDENT LOCALIZATION; SELFISH GENETIC ELEMENTS; TARGETED MESSENGER-RNAS; DOUBLE-STRANDED-RNA; NUCLEAR EXPORT; CHAPERONE MACHINERY; STRUCTURAL BASIS; GUIDE STRAND;
D O I
10.1016/j.bbagrm.2015.08.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs, and PIWI-interacting RNAs, assemble with Argonaute (Ago) family proteins into the effector complex called RNA-induced silencing complex (RISC), which mediates sequence-specific target gene silencing. RISC assembly is not a simple binding between a small RNA and Ago; rather, it follows an ordered multi-step pathway that requires specific accessory factors. Some steps of RISC assembly and RISC-mediated gene silencing are dependent on or facilitated by particular intracellular platforms, suggesting their spatial regulation. In this review, we summarize the currently known mechanisms for RISC assembly of each small RNA class and propose a revised model for the role of the chaperone machinery in the duplex-initiated RISC assembly pathway. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:71 / 81
页数:11
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