A decade of molecular pathogenomic analysis of group A Streptococcus

被引：64

作者：

Musser, James M. ^{[1
,2
]}

Shelburne, Samuel A., III ^{[3
]}

机构：

[1] Methodist Hosp, Res Inst, Ctr Mol & Translat Human Infect Dis Res, Houston, TX 77030 USA

[2] Methodist Hosp, Dept Pathol, Houston, TX 77030 USA

[3] Univ Texas Houston, MD Anderson Canc Ctr, Div Internal Med, Dept Infect Dis, Houston, TX 77030 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 09期

关键词：

COMPLETE GENOME SEQUENCE; VIRULENCE FACTOR EXPRESSION; GENE REGULATORY SYSTEM; ESCHERICHIA-COLI; TRANSCRIPTOME ANALYSIS; CYSTEINE PROTEINASE; ENHANCED VIRULENCE; PYOGENES REVEALS; STRUCTURAL BASIS; SURFACE PROTEIN;

D O I：

10.1172/JCI38095

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated a systems biology investigative strategy designed to enhance and accelerate our understanding of disease processes. Here, we provide examples of the progress made by exploiting an integrated genome-wide research platform to gain new insight into molecular pathogenesis. The studies have provided many new avenues for basic and translational research.

引用

收藏

页码：2455 / 2463

页数：9

相关论文

共 126 条

[1] Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin [J].

Abbot, Emily L. ;

Smith, Wendy D. ;

Siou, Gerard P. S. ;

Chiriboga, Carlos ;

Smith, Rebecca J. ;

Wilson, Janet A. ;

Hirst, Barry H. ;

Kehoe, Michael A. .

CELLULAR MICROBIOLOGY, 2007, 9 (07) :1822-1833

[2] An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis [J].

Abdeltawab, Nourtan F. ;

Aziz, Ramy K. ;

Kansal, Rita ;

Rowe, Sarah L. ;

Su, Yin ;

Gardner, Lidia ;

Brannen, Charity ;

Nooh, Mohammed M. ;

Attia, Ramy R. ;

Abdelsamed, Hossam A. ;

Taylor, William L. ;

Lu, Lu ;

Williams, Robert W. ;

Kotb, Malak .

PLOS PATHOGENS, 2008, 4 (04)

[3] Susceptibility to severe streptococcal sepsis: use of a large set of isogenic mouse lines to study genetic and environmental factors [J].

Aziz, R. K. ;

Kansal, R. ;

Abdeltawab, N. F. ;

Rowe, S. L. ;

Su, Y. ;

Carrigan, D. ;

Nooh, M. M. ;

Attia, R. R. ;

Brannen, C. ;

Gardner, L. A. ;

Lu, L. ;

Williams, R. W. ;

Kotb, M. .

GENES AND IMMUNITY, 2007, 8 (05) :404-415

[4] Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes [J].

Aziz, RK ;

Edwards, RA ;

Taylor, WW ;

Low, DE ;

McGeer, A ;

Kotb, M .

JOURNAL OF BACTERIOLOGY, 2005, 187 (10) :3311-3318

[5] Progress toward characterization of the group a Streptococcus metagenome:: Complete genome sequence of a macrolide-resistant serotype M6 strain [J].

Banks, DJ ;

Porcella, SF ;

Barbian, KD ;

Beres, SB ;

Philips, LE ;

Voyich, JM ;

DeLeo, FR ;

Martin, JM ;

Somerville, GA ;

Musser, JM .

JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (04) :727-738

[6] Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus [J].

Beres, SB ;

Richter, EW ;

Nagiec, MJ ;

Sumby, P ;

Porcella, SF ;

Deleo, FR ;

Musser, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7059-7064

[7] Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections [J].

Beres, SB ;

Sylva, GL ;

Sturdevant, DE ;

Granville, CN ;

Liu, MY ;

Ricklefs, SM ;

Whitney, AR ;

Parkins, LD ;

Hoe, NP ;

Adams, GJ ;

Low, DE ;

DeLeo, FR ;

McGeer, A ;

Musser, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11833-11838

[8] Genome sequence of a serotype M3 strain of group A Streptococcus:: Phage-encoded toxins, the high-virulence phenotype, and clone emergence [J].

Beres, SB ;

Sylva, GL ;

Barbian, KD ;

Lei, BF ;

Hoff, JS ;

Mammarella, ND ;

Liu, MY ;

Smoot, JC ;

Porcella, SF ;

Parkins, LD ;

Campbell, DS ;

Smith, TM ;

McCormick, JK ;

Leung, DYM ;

Schlievert, PM ;

Musser, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10078-10083

[9] Contribution of Exogenous Genetic Elements to the Group A Streptococcus Metagenome [J].

Beres, Stephen B. ;

Musser, James M. .

PLOS ONE, 2007, 2 (08)

[10] Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenes [J].

Bessen, DE ;

Kalia, A .

INFECTION AND IMMUNITY, 2002, 70 (03) :1159-1167

← 1 2 3 4 5 6 7 8 9 10 →