Pharmacosomes: the lipid-based new drug delivery system

被引：109

作者：

Semalty, Ajay ^{[1
]}

Semalty, Mona ^{[1
]}

Rawat, Balwant Singh ^{[1
]}

Singh, Devendra ^{[2
]}

Rawat, M. S. M. ^{[2
]}

机构：

[1] HNB Garhwal Univ Srinagar, Dept Pharmacal Sci, Garhwal 246174, India

[2] HNB Garhwal Univ Srinagar, Dept Chem, Garhwal 246174, India

来源：

EXPERT OPINION ON DRUG DELIVERY | 2009年 / 6卷 / 06期

关键词：

bioavailability; non-steroidal anti-inflammatory drugs; pharmacosome; phospholipid complex; PHOSPHOLIPID COMPLEX; BIODEGRADABLE NANOPARTICLES; ZWITTERIONIC PHOSPHOLIPIDS; TARDIVE-DYSKINESIA; ORAL DELIVERY; IN-VIVO; LECITHIN; ACID; RATS; DISEASE;

D O I：

10.1517/17425240902967607

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lipid-based drug delivery systems have been investigated in various studies and shown their potential in controlled and targeted drug delivery. Pharmacosomes are amphiphilic phospholipid complexes of drugs bearing active hydrogen that bind to phospholipids. Pharmacosomes impart better biopharmaceutical properties to the drug, resulting in improved bioavailability. Pharmacosomes have been prepared for various non-steroidal anti-inflammatory drugs, proteins, cardiovascular and antineoplastic drugs. Developing the pharmacosomes of the drugs has been found to improve the absorption and minimize the gastrointestinal toxicity. This article reviews the potential of pharmacosomes as a controlled and targeted drug delivery system and highlights the methods of preparation and characterization.

引用

页码：599 / 612

页数：14

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