Palladium (0) catalyzed nucleophilic substitution on 2-cyclopropylidene-phenoxy ethanes.

被引：7
作者：
Bernard, AM [1 ]
Piras, PP [1 ]
机构：
[1] UNIV CAGLIARI, DIPARTIMENTO SCI CHIM, I-09100 CAGLIARI, ITALY
来源：
SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 05期
关键词：
D O I：
10.1080/00397919708004192
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-cyclopropylidene-phenoxy ethanes 5, 2-substituted with alkyl, aryl or heterocyclic groups are readily obtained in high yields by the Wittig reaction of the easily accessible a-phenoxy etanones 4 with (3-bromo propyl) triphenylphosphonium bromide. They react with complete regioselectivity in palladium (0) catalyzed nucleophilic substitutions with a series of soft carbon nucleophiles giving an easy entry to 5,6-methanoamino acids.
引用
收藏
页码：709 / 723
页数：15
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