Palladium (0) catalyzed nucleophilic substitution on 2-cyclopropylidene-phenoxy ethanes.

被引：7

作者：

Bernard, AM ^{[1
]}

Piras, PP ^{[1
]}

机构：

[1] UNIV CAGLIARI, DIPARTIMENTO SCI CHIM, I-09100 CAGLIARI, ITALY

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 05期

关键词：

D O I：

10.1080/00397919708004192

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-cyclopropylidene-phenoxy ethanes 5, 2-substituted with alkyl, aryl or heterocyclic groups are readily obtained in high yields by the Wittig reaction of the easily accessible a-phenoxy etanones 4 with (3-bromo propyl) triphenylphosphonium bromide. They react with complete regioselectivity in palladium (0) catalyzed nucleophilic substitutions with a series of soft carbon nucleophiles giving an easy entry to 5,6-methanoamino acids.

引用

页码：709 / 723

页数：15

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