Medicinal attributes of pyridine scaffold as anticancer targeting agents

被引：59

作者：

Mohamed, Esraa Ali ^{[1
]}

Ismail, Nasser S. M. ^{[2
]}

Hagras, Mohamed ^{[3
]}

Refaat, Hanan ^{[1
]}

机构：

[1] Future Univ Egypt, Fac Pharmaceut Sci & Pharmaceut Ind, Dept Pharmaceut Chem, Cairo, Egypt

[2] Ain Shams Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt

[3] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt

来源：

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES | 2021年 / 7卷 / 01期

关键词：

Pyridines; Anticancer; Cytotoxic action; Tyrosine kinases; NF-KAPPA-B; BIOLOGICAL EVALUATION; DERIVATIVES; DESIGN; CANCER; ANGIOGENESIS; INHIBITORS; CDK9; EGFR;

D O I：

10.1186/s43094-020-00165-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: The heterocyclic compounds particularly pyridine displayed clinical and biological implementation. Pyridine scaffolds have been detected in most relevant drug molecules that included pyridine provided a great possibility for treatment. Main text: Pyridine-containing compounds have increasing importance for medicinal application as antiviral, anticholinesterase activities, antimalarial, antimicrobial, antidiabetic and anticancer. This has generated concern among researchers in synthesising a variety of pyridine derivatives. Conclusion: This review focuses on different pyridine targets as anticancer and their pharmacophoric elements controlling its activity.

引用

页数：17