Gabapentin-Induced Rhabdomyolysis in a Patient with Diabetic Neuropathy

被引：10
|
作者：
Bilgir, Oktay [1 ]
Calan, Mehmet [1 ]
Bilgir, Ferda [2 ]
Kebapcilar, Levent [1 ]
Yuksel, Arif [1 ]
Yildiz, Yasar [1 ]
Sari, Ismail [1 ]
机构：
[1] Izmir Bozyaka Educ & Res Hosp, Dept Internal Med 2, Izmir, Turkey
[2] Buca State Hosp, Dept Internal Med, Izmir, Turkey
来源：
INTERNAL MEDICINE | 2009年 / 48卷 / 12期
关键词：
Gabapentin; rhabdomyolysis; diabetic neuropathy; RENAL-FAILURE; MYOPATHY; PAIN;
D O I：
10.2169/internalmedicine.48.1766
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gabapentin (GBP) is a drug which is frequently used in diabetic neuropathy. Common adverse effects of GBP include drowsiness, dizziness, ataxia, somnolence, and fatigue. Rhabdomyolysis is an extremely rare side effect of GBP. In this report we describe a case of GBP-induced rhabdomyolysis in a 63-year-old diabetic woman. She presented with severe muscle pain in her extremities, fatigue, decreased urine output and urine discoloration within 3 weeks after starting treatment with GBP (900 mg/day) for diabetic neuropathy. Laboratory tests revealed extreme elevations of muscle enzymes, increased creatinine and potassium levels. She required hemodialysis as a result of anuria. Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of GBP resulted in resolution of clinical and biochemical features of rhabdomyolysis.
引用
收藏
页码：1085 / 1087
页数：3
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