Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases'

被引：86

作者：

Murphy, Gillian ^{[1
]}

机构：

[1] Univ Cambridge, Dept Oncol, Cambridge CB2 1TN, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2009年 / 20卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ADAM; Disintegrin metalloproteinase; Sheddase; Review; TUMOR-NECROSIS-FACTOR; ALPHA-CONVERTING-ENZYME; EPIDERMAL-GROWTH-FACTOR; AMYLOID-PRECURSOR-PROTEIN; CANCER-CELL-PROLIFERATION; EGF RECEPTOR ACTIVATION; SH3 DOMAIN BINDING; TNF-ALPHA; CYTOPLASMIC DOMAIN; ADAM PROTEASES;

D O I：

10.1016/j.semcdb.2008.09.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proteolytically functional ADAMs, of which there are 13 in the human, play key roles in the way that many different types of cells respond to their environment. They act as 'signalling scissors' within various membrane environments, including at the cell surface, orchestrating rapid changes in the status of their transmembrane protein substrates. The elucidation of the mode of regulation of these 'shedding' activities is consequently of pivotal importance in the understanding their roles, but is still rather understudied, with large gaps in our knowledge. This review will consider the major regulatory mechanisms that are known which indicate where further research is needed. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：138 / 145

页数：8

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