EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy: A retrospective study and literature review

Objective: Although neuroimaging and electrophysiological tests are potentially useful to distinguish corticobasal degeneration (CBD) from progressive supranuclear palsy (PSP), little is known about the diagnostic value of electroencephalography (EEG) for their distinction. We assessed the value of EEG for differentiating CBD from PSP. Methods: We reviewed conventional EEGs recorded at an early stage of disease in 10 CBD patients and 14 PSP patients. We focused on slowing of background activity (SBA), frontal intermittent rhythmic delta activity (FIRDA) and focal slow waves (FSWs). Statistical analysis was performed by Fisher's exact test. Results: SBA was observed in 1 CBD patient and 2 PSP patients. FSWs were found in 8 CBD patients (80.0%), but only 2 PSP patients (14.3%) (p = 0.002); they appeared contralateral to the dominantly-affected side in 6 of 8 CBD patients, and ipsilateral to the side with most atrophy on MRI in 7 of 8 CBD patients. FIRDA was observed in 2 CBD patients (20.0%) and 5 PSP patients (35.7%) (P = 0.357). Conclusions: FSWs are characteristic of CBD, but FIRDA was not disease-specific. Significance: FSWs on EEG, in addition to clinical criteria, yield useful supplementary information to distinguish between these diseases at early stages. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.