High-performance liquid chromatographic method for the determination of gabapentin in human plasma

被引：61

作者：

Zhu, Z ^{[1
]}

Neirinck, L ^{[1
]}

机构：

[1] Pharmasci, Montreal, PQ H4P 2T4, Canada

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2002年 / 779卷 / 02期

关键词：

gabapentin;

D O I：

10.1016/S1570-0232(02)00399-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive high-performance liquid chromatography (HPLC) method using UV detection for the determination of gabapentin in human plasma has been developed. In this method, gabapentin was extracted from human plasma with a reversed-phase solid-phase extraction (SPE) cartridge followed by derivatization with phenylisothiocyanate. Analysis was achieved by using a HPLC system that was equipped with a UV detector. The quantitation limit of gabapentin. in human plasma was 0.03 mug/ml. The method is sensitive with excellent selectivity and reproducibility and it has been applied to a bioequivalence clinical study with great success. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：307 / 312

页数：6

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