Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7

被引：57

作者：

Manaviazar, Soraya ^{[1
]}

Frigerio, Mark ^{[1
]}

Bhatia, Gurpreet S. ^{[1
]}

Hummersone, Marc G. ^{[1
]}

Aliev, Abil E. ^{[1
]}

Hale, Karl J. ^{[1
]}

机构：

[1] UCL, Ctr Chem Genom, Christopher Ingold Labs, Dept Chem, London WC1H 0AJ, England

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 20期

关键词：

D O I：

10.1021/ol061626i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new enantioselective synthesis of Masamune's AB fragment (1) for bryostatin 7 is described. Key steps in the new route include a Meerwein-Ponndorf -Verley reduction to set the O(7) stereocenter and an alkylative union between the dithiane 6 and iodide 5 to construct the C(9) C(10) bond. Because we have previously published a synthesis of Masamune's C-ring phenyl sulfone 2, our new route to 1 constitutes a formal total synthesis of bryostatin 7; it also corrects the previously reported spectral data for 1 in CDCl3.

引用

页码：4477 / 4480

页数：4

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