Use of a Cyclometalated Iridium(III) Complex Containing a N∧C∧N-Coordinating Terdentate Ligand as a Catalyst for the α-Alkylation of Ketones and N-Alkylation of Amines with Alcohols

被引：67

作者：

Liu, Pengcheng ^{[1
]}

Lang, Ran ^{[1
]}

Lu, Lei ^{[1
]}

Yu, Zhentao ^{[2
]}

Li, Feng ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

[2] Nanjing Univ, Coll Engn & Appl Sci, Jiangsu Key Lab Nano Technol, Nanjing 210093, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 04期

基金：

中国国家自然科学基金;

关键词：

TRANSITION-METAL; CHEMOSELECTIVE HYDROGENATION; SELECTIVE ALKYLATION; RECYCLABLE CATALYST; REDUCTIVE AMINATION; EFFICIENT CATALYSTS; BORROWING HYDROGEN; PALLADIUM CATALYST; HIGHLY EFFICIENT; WATER OXIDATION;

D O I：

10.1021/acs.joc.6b02758

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cyclometalated iridium(III) complex containing a N boolean AND C boolean AND N-coordinating terdentate ligand [Ir(dpyx-N,C,N)-Cl(mu-Cl)](2) was found to be a general and highly effective catalyst for the a-alkylation of ketones and N-alkylation of amines with alcohols. In the presence of catalyst (1 mol % Ir) and base (0.2-0.5 equiv), a variety of desirable products were obtained in good yields under an air atmosphere. Notably, this research exhibited the new potential of Ir(III) complexes bearing non-Cp* ligand and will facilitate the progress of the hydrogen autotransfer process.

引用

页码：1943 / 1950

页数：8

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