P-Rex2, a new guanine-nucleotide exchange factor for Rac

被引：84

作者：

Donald, S

Hill, K

Lecureuil, C

Barnouin, R

Krugmann, S

Coadwell, WJ

Andrews, SR

Walker, SA

Hawkins, PT

Stephens, LR

Welch, HCE ^{[1
]}

机构：

[1] Babraham Inst, Inositide Lab, Signalling Programme, Cambridge CB2 4AT, England

[2] Babraham Inst, Bioinfomat Grp, Cambridge CB2 4AT, England

[3] Babraham Inst, Mol Signalling Lab, Cambridge CB2 4AT, England

来源：

FEBS LETTERS | 2004年 / 572卷 / 1-3期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

P-Rex2; P-Rex1; GEF; Rac; PI3K; G beta gamma subunits;

D O I：

10.1016/j.febslet.2004.06.096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It has widespread tissue distribution but is not expressed in neutrophils. P-Rex2 is a 183 kDa protein that activates the small GTPase Rac and is regulated by phosphatidylinositol (3,4,5)-trisphosphate and the betagamma subunits of heterotrimeric G proteins in vitro and in vivo. P-Rex2 has structure, activity and regulatory properties similar to P-Rex1 but has divergent tissue distribution, as P-Rex1 is mainly expressed in neutrophils. Together, they form an enzyme family capable of mediating Rac signalling downstream of G protein-coupled receptors and phosphoinositide 3-kinase. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：172 / 176

页数：5

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