The complex of zinc with N-(5,6-dihydro-4H-1,3-thiazine-2-yl)benzamide

被引：6

作者：

Trofimova, T. P. ^{[1
,2
]}

Orlova, M. A. ^{[1
,2
]}

Severin, A. V. ^{[1
]}

Shalamova, E. S. ^{[1
]}

Proshin, A. N. ^{[3
]}

Orlov, A. P. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Bld 3,1 Leninskie Gory, Moscow 119991, Russia

[2] D Rogachev Natl Res Clin Ctr Pediat Hematol Oncol, 1 Ul Samory Mashela, Moscow 117997, Russia

[3] Russian Acad Sci, Inst Physiol Act Cpds, 1 Severnyi Proezd, Chernogolovka 142432, Moscow Region, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2018年 / 67卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

dihydrotiazine derivatives; zinc complex; stability; protonation constant; sorption on hydroxyapatite; STRUCTURAL-CHARACTERIZATION; PHAGOCYTIC-ACTIVITY; DERIVATIVE LIGANDS; HUMAN NEUTROPHILS; CRYSTAL-STRUCTURE; ACID; SALICYLATE; CELLS; ASPIRIN;

D O I：

10.1007/s11172-018-2135-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A complex of zinc with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide (L) ligand, LZnCl2, was synthesized for subsequent medical trials. The molar extinction coefficients were determined for LHBr solutions in water and physiological saline, and for LZnCl2 ethanol solution. The ligand stability in various solvents was evaluated and the value of its protonation constant was found for the physiological saline solution, logK = 5.3 +/- 0.2. The impossibility of determination of the complex stability constant by the potentiometric titration method was demonstrated. The complex exhibited an insufficient stability in aqueous and physiological saline solutions, but was stable as the solution in alcohol. There was no sorption observed upon the treatment of ligand with hydroxyapatite nanoparticles, which could be a potential carrier for the therapeutic form of LZnCl2, providing additional degrees of freedom for the interaction of ligand with cell membranes and a prolonged action of zinc ions.

引用

页码：768 / 773

页数：6

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