Correcting for confounding in analyzing receiver operating characteristic curves

被引：16

作者：

Smith, PJ ^{[1
]}

Thompson, TJ ^{[1
]}

机构：

[1] CTR DIS CONTROL & PREVENT,DIV DIABET TRANSLAT K10,ATLANTA,GA 30341

来源：

BIOMETRICAL JOURNAL | 1996年 / 38卷 / 07期

关键词：

area under the curve; probability plot; screening; sensitivity; specificity; Weibull distribution;

D O I：

10.1002/bimj.4710380711

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A method is described for modeling a receiver operating curve as a function of confounding covariates when the outcome of the screening test is a continuous variate. A parametric survival model is proposed for modeling the distribution of the screening test outcome as a function of true disease status and other confounding covariates. The sensitivity and specificity of the screening test at any ''cut-point'' along the range of the screening test outcome may be estimated easily from the estimated survival distribution. Confidence intervals and an estimate of the area under the curve are derived.

引用

页码：857 / 863

页数：7

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