Sulfonamide-Bridged Nucleic Acid: Synthesis, High RNA Selective Hybridization, and High Nuclease Resistance

被引：22

作者：

Mitsuoka, Yasunori ^{[1
,2
]}

Fujimura, Yuko ^{[2
]}

Waki, Reiko ^{[1
]}

Kugimiya, Akira ^{[2
]}

Yamamoto, Tsuyoshi ^{[1
]}

Hari, Yoshiyuki ^{[1
]}

Obika, Satoshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] Shionogi & Co Ltd, Discovery Res Lab Innovat Frontier Med, Toyonaka, Osaka 5610825, Japan

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 21期

关键词：

ANTISENSE OLIGONUCLEOTIDES; NUCLEOSIDE ANALOGS; DUPLEX STABILITY; LNA; RECOGNITION; ENA; 5-METHYLCYTOSINE; 2'; 4'-BNA(NC); THYMIDINES; MONOMERS;

D O I：

10.1021/ol503029v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2'-N,4'-C-(N-Methylamino)sulfonylmethylene-bridged thymidine (SuNA), which has a six-membered linkage including a sulfonamide moiety, was synthesized and introduced into oligonucleotides. The oligonucleotides containing SuNA exhibited excellent nuclease resistance, a high affinity toward single-stranded RNA, and a low affinity toward single-stranded DNA compared to the natural oligonucleotide.

引用

页码：5640 / 5643

页数：4

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