Molecular forms of alpha-melanocyte-stimulating hormone in pheochromocytoma tissue

被引：3

作者：

Gardi, J ^{[1
]}

Khalil, WK ^{[1
]}

Vecsernyés, M ^{[1
]}

Gáspár, L ^{[1
]}

Szécsi, M ^{[1
]}

Julesz, J ^{[1
]}

机构：

[1] Albert Szent Gyorgyi Med Univ, Endocrine Unit, H-6701 Szeged, Hungary

来源：

ENDOCRINE RESEARCH | 2000年 / 26卷 / 01期

关键词：

D O I：

10.1080/07435800009040147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The molecular forms of alpha-melanocyte-stimulating hormone (MSH) in pheochromocytoma tissues have been characterized using reversed-phase HPLC and radioimmunoassay. Six alpha-MSH-related peptides were detected. Three of the six peaks had elution times identical to those of synthetic desacetyl-alpha-MSH, alpha-MSH and diacetyl-alpha-MSH. The remaining three forms of the alpha-MSH-like immunoreactivity suggest a different processing of proopiomelanocortin in this tissue than in the intermediate lobe of the pituitary gland. Current results confirm that alpha-MSH are present in human pheochromocytoma and suggest that alpha-MSH has role in the pathophysiology of this tissue.

引用

页码：71 / 79

页数：9

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