Structural basis of mRNA cap recognition by proteins

被引：68

作者：

Quiocho, FA ^{[1
]}

Hu, GH

Gershon, PD

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Dept Biochem, Houston, TX 77030 USA

[2] Baylor Coll Med, Grad Program Mol Biophys, Houston, TX 77030 USA

[3] Texas A&M Univ, Inst Biosci & Technol, Syst Hlth Sci Ctr, Houston, TX 77030 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(99)00053-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crystal structures have recently become available for two proteins (VP39 and elF4E) complexed with their cognate ligand - the mRNA cap, Despite their total structural dissimilarity, both proteins bind N7-methylguanine between two parallel aromatic sidechains, The resulting stacked arrangement governs their high specificity for the alkylated form of the nucleobase.

引用

页码：78 / 86

页数：9

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