Renal function is associated with blood neurofilament light chain level in older adults

被引：145

作者：

Akamine, Shoshin ^{[1
,2
]}

Marutani, Noriko ^{[2
,3
]}

Kanayama, Daisuke ^{[1
,2
,4
]}

Gotoh, Shiho ^{[4
]}

Maruyama, Riki ^{[4
]}

Yanagida, Kanta ^{[1
,2
]}

Sakagami, Yukako ^{[1
,2
]}

Mori, Kohji ^{[4
]}

Adachi, Hiroyoshi ^{[1
,2
,4
]}

Kozawa, Junji ^{[5
,6
]}

Maeda, Norikazu ^{[5
,7
]}

Otsuki, Michio ^{[5
]}

Matsuoka, Takaaki ^{[5
]}

Iwahashi, Hiromi ^{[5
,6
,8
]}

Shimomura, Iichiro ^{[5
]}

Ikeda, Manabu ^{[4
]}

Kudo, Takashi ^{[1
,2
,4
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Mental Hlth Promot, Suita, Osaka, Japan

[2] Osaka Univ, Hlth & Counseling Ctr, Toyonaka, Osaka, Japan

[3] Osaka Univ, Grad Sch Med, Dept Psychol Hlth Promot, Suita, Osaka, Japan

[4] Osaka Univ, Dept Psychiat, Grad Sch Med, Suita, Osaka, Japan

[5] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka, Japan

[6] Osaka Univ, Dept Diabet Care Med, Grad Sch Med, Suita, Osaka, Japan

[7] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, Suita, Osaka, Japan

[8] Toyonaka City Hosp, Dept Internal Med, Osaka, Japan

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

基金：

日本学术振兴会;

关键词：

ERYTHROPOIETIN; BIOMARKER; RECEPTOR; INJURY;

D O I：

10.1038/s41598-020-76990-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n=43, serum NfL) and patients with diabetes mellitus (n=188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r=0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.

引用

页数：7

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