Doubly dearomatising intramolecular coupling of a nucleophilic and an electrophilic heterocycle

被引：15

作者：

Brice, Heloise ^{[1
]}

Clayden, Jonathan ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 15期

关键词：

STEREOSELECTIVE-SYNTHESIS; REGIOSELECTIVE-SYNTHESIS; PRIVILEGED STRUCTURES; CYCLIZATION; ACID; DERIVATIVES; ANTAGONISTS; GROWTH; FURAN; MODEL;

D O I：

10.1039/b901558b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Isonicotinamides carrying N-furanylmethyl, N-pyrrolylalkyl or N-thiophenylmethyl substituents at nitrogen undergo cyclisation induced by an electrophile, giving spirocyclic compounds or doubly spirocyclic compounds in which both the nucleophilic and electrophilic heterocycles are dearomatised.

引用

页码：1964 / 1966

页数：3

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