The efficacy of anti-CD19 chimeric antigen receptor T cells for B-cell malignancies

被引：15

作者：

Cao, Jun-Xia ^{[1
]}

Gao, Wei-Jian ^{[1
]}

You, Jia ^{[1
]}

Wu, Li-Hua ^{[1
]}

Liu, Jin-Long ^{[1
]}

Wang, Zheng-Xu ^{[1
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Biotherapy Ctr, Med Ctr 7, 5 Nan Men Cang Rd, Beijing 100700, Peoples R China

来源：

CYTOTHERAPY | 2019年 / 21卷 / 07期

基金：

中国国家自然科学基金;

关键词：

CAR-T; acute lymphocytic leukemia; chronic lymphocytic leukemia; lymphomas; meta-analysis; CD19; REMISSIONS; IMMUNOTHERAPY; PERSISTENCE; CHILDREN; LEUKEMIA; THERAPY; SAFETY; LYMPHOMA; INFUSION;

D O I：

10.1016/j.jcyt.2019.04.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Immunotherapy with chimeric antigen receptor T (CAR-T) cells has proved remarkably effective in recently published clinical trials. In this meta-analysis, we performed a systematic review in terms of the clinical response treated with CAR-T cells in acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL) and lymphomas patients. Thirty-eight published clinical studies including 665 patients were eligible for response rate (RR) evaluation. The overall pooled RR of CD19-CAR-T cells was 72% (95% confidence interval: 62-77%). The various clinical parameters were analyzed. RR was 81% in ALL, 68% in lymphoma and 70% in CLL. RR in patients who received interleukin (IL)-2 was 70%, whereas in those who did not receive IL-2, it was 74%. RR was 75% with lymphodepletion and 56% without lymphodepletion. RR with autologous cells was 76% and 57% with allogeneic cells. In conclusion, this meta-analysis showed a high clinical RR of CD19-CAR-T cell-based immunotherapy in patients with refractory B-cell malignancies.

引用

页码：769 / 781

页数：13

共 57 条

[1] Utility and prognostic value of 18F-FDG PET/CT scan in patients with newly diagnosed multiple myeloma. [J].

Aljama, Mohammed A. ;

Sidiqi, M. Hasib ;

Kumar, Shaji ;

Kourelis, Taxiarchis ;

Gertz, Morie A. ;

Rajkumar, S. Vincent ;

Gonsalves, Wilson I. ;

Lacy, Martha ;

Buadi, Francis ;

Kapoor, Prashant ;

Dispenzieri, Angela ;

Dingli, David ;

Leung, Nelson ;

Lust, John Anthony ;

Hayman, Suzanne R. ;

Go, Ronald S. ;

Hwa, Lisa ;

Kyle, Robert A. ;

Warsame, Rahma M. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)

[2] Donor origin CAR T cells: graft versus malignancy effect without GVHD, a systematic review [J].

Anwer, Faiz ;

Shaukat, Al-Aman ;

Zahid, Umar ;

Husnain, Muhammad ;

McBride, Ali ;

Persky, Daniel ;

Lim, Melissa ;

Hasan, Nida ;

Bin Riaz, Irbaz .

IMMUNOTHERAPY, 2017, 9 (02) :123-130

[3] Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy [J].

Bhoj, Vijay G. ;

Arhontoulis, Dimitrios ;

Wertheim, Gerald ;

Capobianchi, James ;

Callahan, Colleen A. ;

Ellebrecht, Christoph T. ;

Obstfeld, Amrom E. ;

Lacey, Simon F. ;

Melenhorst, Jan J. ;

Nazimuddin, Farzana ;

Hwang, Wei-Ting ;

Maude, Shannon L. ;

Wasik, Mariusz A. ;

Bagg, Adam ;

Schuster, Stephen ;

Feldman, Michael D. ;

Porter, David L. ;

Grupp, Stephen A. ;

June, Carl H. ;

Milone, Michael C. .

BLOOD, 2016, 128 (03) :360-370

[4] CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia [J].

Brentjens, Renier J. ;

Davila, Marco L. ;

Riviere, Isabelle ;

Park, Jae ;

Wang, Xiuyan ;

Cowell, Lindsay G. ;

Bartido, Shirley ;

Stefanski, Jolanta ;

Taylor, Clare ;

Olszewska, Malgorzata ;

Borquez-Ojeda, Oriana ;

Qu, Jinrong ;

Wasielewska, Teresa ;

He, Qing ;

Bernal, Yvette ;

Rijo, Ivelise V. ;

Hedvat, Cyrus ;

Kobos, Rachel ;

Curran, Kevin ;

Steinherz, Peter ;

Jurcic, Joseph ;

Rosenblat, Todd ;

Maslak, Peter ;

Frattini, Mark ;

Sadelain, Michel .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (177)

[5] Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias [J].

Brentjens, Renier J. ;

Riviere, Isabelle ;

Park, Jae H. ;

Davila, Marco L. ;

Wang, Xiuyan ;

Stefanski, Jolanta ;

Taylor, Clare ;

Yeh, Raymond ;

Bartido, Shirley ;

Borquez-Ojeda, Oriana ;

Olszewska, Malgorzata ;

Bernal, Yvette ;

Pegram, Hollie ;

Przybylowski, Mark ;

Hollyman, Daniel ;

Usachenko, Yelena ;

Pirraglia, Domenick ;

Hosey, James ;

Santos, Elmer ;

Halton, Elizabeth ;

Maslak, Peter ;

Scheinberg, David ;

Jurcic, Joseph ;

Heaney, Mark ;

Heller, Glenn ;

Frattini, Mark ;

Sadelain, Michel .

BLOOD, 2011, 118 (18) :4817-4828

[6] Chimeric antigen receptor T-cell therapies for lymphoma [J].

Brudno, Jennifer N. ;

Kochenderfer, James N. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2018, 15 (01) :31-46

[7] Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease [J].

Brudno, Jennifer N. ;

Somerville, Robert P. T. ;

Shi, Victoria ;

Rose, Jeremy J. ;

Halverson, David C. ;

Fowler, Daniel H. ;

Gea-Banacloche, Juan C. ;

Pavletic, Steven Z. ;

Hickstein, Dennis D. ;

Lu, Tangying L. ;

Feldman, Steven A. ;

Iwamoto, Alexander T. ;

Kurlander, Roger ;

Maric, Irina ;

Goy, Andre ;

Hansen, Brenna G. ;

Wilder, Jennifer S. ;

Blacklock-Schuver, Bazetta ;

Hakim, Frances T. ;

Rosenberg, Steven A. ;

Gress, Ronald E. ;

Kochenderfer, James N. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (10) :1112-+

[8] Potent anti-leukemia activities of humanized CD19-targeted Chimeric antigen receptor T (CAR-T) cells in patients with relapsed/refractory acute lymphoblastic leukemia [J].

Cao, Jiang ;

Wang, Gang ;

Cheng, Hai ;

Wei, Chen ;

Qi, Kunming ;

Sang, Wei ;

Li Zhenyu ;

Shi, Ming ;

Li, Huizhong ;

Qiao, Jianlin ;

Pan, Bin ;

Zhao, Jing ;

Wu, Qingyun ;

Zeng, Lingyu ;

Niu, Mingshan ;

Jing, Guangjun ;

Zheng, Junnian ;

Xu, Kailin .

AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (07) :851-858

[9] Donor-derived CD19-targeted T cell infusion induces minimal residual disease-negative remission in relapsed B-cell acute lymphoblastic leukaemia with no response to donor lymphocyte infusions after haploidentical haematopoietic stem cell transplantation [J].

Chen, Yuhong ;

Cheng, Yifei ;

Suo, Pan ;

Yan, Chenhua ;

Wang, Yu ;

Chen, Yao ;

Han, Wei ;

Xu, Lanping ;

Zhang, Xiaohui ;

Liu, Kaiyan ;

Chang, Lungji ;

Xiao, Lei ;

Huang, Xiaojun .

BRITISH JOURNAL OF HAEMATOLOGY, 2017, 179 (04) :598-605

[10] In Vivo Expansion and Antitumor Activity of Coinfused CD28-and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia [J].

Cheng, Zhi ;

Wei, Runhong ;

Ma, Qiuling ;

Shi, Lin ;

He, Feng ;

Shi, Zixiao ;

Jin, Tao ;

Xie, Ronglin ;

Wei, Baofeng ;

Chen, Jing ;

Fang, Hongliang ;

Han, Xiaolu ;

Rohrs, Jennifer A. ;

Bryson, Paul ;

Liu, Yarong ;

Li, Qi-Jing ;

Zhu, Bo ;

Wang, Pin .

MOLECULAR THERAPY, 2018, 26 (04) :976-985

← 1 2 3 4 5 6 →