Asymmetric iodocyclization of γ-hydroxyalkenes

被引：26

作者：

Kang, SH ^{[1
]}

Park, CM ^{[1
]}

Lee, SB ^{[1
]}

Kim, M ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Sch Mol Sci BK21, Dept Chem, Ctr Mol Design & Synth, Taejon 305701, South Korea

来源：

SYNLETT | 2004年 / 07期

关键词：

reagent-controlled; iodocyclization; gamma-hydroxyalkenes; (R)-Binol-Ti(IV) complex; N-iodosuccinimide;

D O I：

10.1055/s-2004-825593

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective intramolecular iodoetherification of disubstituted gamma-hydroxyalkenes has been intended using NIS in the presence of 0.2 equivalents of (R)-Binol-Ti(IV) complex to procure the corresponding tetrahydrofurans in up to 65% ee.

引用

页码：1279 / 1281

页数：3

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