Type-1 Cannabinoid Receptor Activity During Alzheimer's Disease Progression

被引:50
作者
Manuel, Ivan [1 ]
Gonzalez de San Roman, Estibaliz [1 ]
Teresa Giralt, M. [1 ]
Ferrer, Isidro [2 ]
Rodriguez-Puertas, Rafael [1 ]
机构
[1] Univ Basque Country, Fac Med & Odontol, Dept Pharmacol, E-48940 Leioa, Vizcaya, Spain
[2] Univ Barcelona, CIBERNED, Hosp Univ Bellvitge, Inst Neuropatol,Serv Anat Patol, Lhospitalet De Llobregat, Spain
关键词
Alzheimer's disease; cannabinoid receptors; functional autoradiography; G-protein; ligand binding; COGNITIVE IMPAIRMENT; CB1; RECEPTORS; PATHOLOGY; CORTEX; BINDING; MEMORY; BRAIN;
D O I
10.3233/JAD-140492
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The activity of CB1 cannabinoid receptors was studied in postmortem brain samples of Alzheimer's disease (AD) patients during clinical deterioration. CB1 activity was higher at earlier AD stages in limited hippocampal areas and internal layers of frontal cortex, but a decrease was observed at the advanced stages. The pattern of modification appears to indicate initial hyperactivity of the endocannabinoid system in brain areas that lack classical histopathological markers at earlier stages of AD, indicating an attempt to compensate for the initial synaptic impairment, which is then surpassed by disease progression. These results suggest that initial CB1 stimulation might have therapeutic relevance.
引用
收藏
页码:761 / 766
页数:6
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