Non-coding RNAs as epigenetic regulator of glioma stem-like cell differentiation

被引：29

作者：

Katsushima, Keisuke ^{[1
]}

Kondo, Yutaka ^{[1
]}

机构：

[1] Aichi Canc Ctr, Inst Res, Div Epigen, Chikusa Ku, Nagoya, Aichi 4648681, Japan

来源：

FRONTIERS IN GENETICS | 2014年 / 5卷

关键词：

TUMOR-INITIATING CELLS; HUMAN GLIOBLASTOMA-MULTIFORME; PROSTATE-SPECIFIC GENE; SELF-RENEWAL; NEURONAL DIFFERENTIATION; MALIGNANT GLIOMAS; POOR-PROGNOSIS; HUMAN-DISEASE; X-CHROMOSOME; BRAIN-TUMORS;

D O I：

10.3389/fgene.2014.00014

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Glioblastomas show heterogeneous histological features. These distinct phenotypic states are thought to be associated with the presence of glioma stem cells (GSCs), which are highly tumorigenic and self-renewing sub-population of tumor cells that have different functional characteristics. Differentiation of GSCs may be regulated by multi-tiered epigenetic mechanisms that orchestrate the expression of thousands of genes. One such regulatory mechanism involves functional non-coding RNAs (ncRNAs), such as microRNAs (miRNAs); a large number of ncRNAs have been identified and shown to regulate the expression of genes associated with cell differentiation programs. Given the roles of miRNAs in cell differentiation, it is possible they are involved in the regulation of gene expression networks in GSCs that are important for the maintenance of the pluripotent state and for directing differentiation. Here, we review recent findings on ncRNAs associated with GSC differentiation and discuss how these ncRNAs contribute to the establishment of tissue heterogeneity during glioblastoma tumor formation.

引用

页数：8

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