Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

被引：1294

作者：

Hidalgo, Manuel ^{[1
]}

Amant, Frederic ^{[4
]}

Biankin, Andrew V. ^{[5
]}

Budinska, Eva ^{[8
]}

Byrne, Annette T. ^{[9
]}

Caldas, Carlos ^{[6
]}

Clarke, Robert B. ^{[7
]}

de Jong, Steven ^{[10
]}

Jonkers, Jos ^{[11
]}

Maelandsmo, Gunhild Mari ^{[12
]}

Roman-Roman, Sergio ^{[13
]}

Seoane, Joan ^{[2
]}

Trusolino, Livio ^{[14
,15
]}

Villanueva, Alberto ^{[3
]}

机构：

[1] Ctr Nacl Invest Oncol, Madrid 28029, Spain

[2] Hosp Llobregat, Vall dHebron Inst Oncol, Barcelona, Spain

[3] Hosp Llobregat, Catalan Inst Oncol, Bellvitge Biomed Res Inst, Barcelona, Spain

[4] Katholieke Univ Leuven, Leuven, Belgium

[5] Univ Glasgow, Inst Canc Sci, Wolfson Wohl Canc Res Ctr, Glasgow, Lanark, Scotland

[6] Cambridge Canc Ctr, Cambridge, England

[7] Univ Manchester, Inst Canc Sci, Breakthrough Breast Canc Unit, Manchester, Lancs, England

[8] Masaryk Univ, Brno, Czech Republic

[9] Royal Coll Surgeons Ireland, Dublin 2, Ireland

[10] Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, Groningen, Netherlands

[11] Netherlands Canc Inst, Amsterdam, Netherlands

[12] Oslo Univ Hosp, Oslo, Norway

[13] Inst Curie, Paris, France

[14] Candiolo Canc Inst FPO IRCCS, Turin, Italy

[15] Univ Turin, Dept Oncol, Turin, Italy

来源：

CANCER DISCOVERY | 2014年 / 4卷 / 09期

关键词：

PANCREATIC-CANCER; TUMOR XENOGRAFTS; STEM-CELLS; GENE-EXPRESSION; BASAL-LIKE; METASTASIS; RESISTANCE; GROWTH; HETEROGENEITY; EVOLUTION;

D O I：

10.1158/2159-8290.CD-14-0001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for preclinical drug evaluation, biomarker identification, biologic studies, and personalized medicine strategies. This article summarizes the current state of the art in this field, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and introduces a European consortium of PDX models. Significance: PDX models are increasingly used in translational cancer research. These models are useful for drug screening, biomarker development, and the preclinical evaluation of personalized medicine strategies. This review provides a timely overview of the key characteristics of PDX models and a detailed discussion of future directions in the field. (C) 2014 AACR.

引用

页码：998 / 1013

页数：16

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