Synthesis and synthetic chemistry of pleuromutilin

被引：41
作者：
Fazakerley, Neal J. [1 ]
Procter, David J. [1 ]
机构：
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
来源：
TETRAHEDRON | 2014年 / 70卷 / 39期
基金：
英国工程与自然科学研究理事会;
关键词：
Pleuromutilin; Total synthesis; Medicinal chemistry; Antibacterials; ENHANCED ANTIMICROBIAL ACTIVITY; ACUTE BACTERIAL SKIN; ANTIBACTERIAL ACTIVITY; RELAY APPROACH; DIKETONE INTERMEDIATE; BIOLOGICAL EVALUATION; ANTIBIOTIC BC-3781; DIRECT DEGRADATION; ALLYLIC ALCOHOLS; PART;
D O I：
10.1016/j.tet.2014.05.092
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：6911 / 6930
页数：20
相关论文
共 149 条
[91]  
NAKOV AI, 2003, Patent No. 105644
[92]  
Novak R, 2012, RSC DRUG DISCOV, V25, P326, DOI 10.1039/9781849734950-00326
[93]   Are pleuromutilin antibiotics finally fit for human use? [J].
Novak, Rodger .
ANTIMICROBIAL THERAPEUTICS REVIEWS: ANTIBIOTICS THAT TARGET THE RIBOSOME, 2011, 1241 :71-81
[94]  
Novak R, 2010, CURR OPIN INVEST DR, V11, P182
[95]   A RELAY APPROACH TO (+)-PLEUROMUTILIN .1. DENOVO SYNTHESIS OF A LEVOROTATORY TRICYCLIC LACTONE SUBUNIT [J].
PAQUETTE, LA ;
WIEDEMAN, PE .
TETRAHEDRON LETTERS, 1985, 26 (13) :1603-1606
[96]   A RELAY APPROACH TO (+)-PLEUROMUTILIN .3. DIRECT DEGRADATION OF THE NATURAL PRODUCT TO THE KEY DIKETONE INTERMEDIATE AND ITS CHEMOSPECIFIC FUNCTIONALIZATION [J].
PAQUETTE, LA ;
WIEDEMAN, PE ;
BULMANPAGE, PC .
TETRAHEDRON LETTERS, 1985, 26 (13) :1611-1614
[97]   (+)-PLEUROMUTILIN SYNTHETIC STUDIES - DEGRADATIVE AND DENOVO ACQUISITION OF A LEVOROTATORY TRICYCLIC LACTONE SUBUNIT [J].
PAQUETTE, LA ;
WIEDEMAN, PE ;
BULMANPAGE, PC .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (07) :1441-1450
[98]   (+)-PLEUROMUTILIN SYNTHETIC STUDIES - DIRECT DEGRADATION TO AND INDEPENDENT PREPARATION OF AN ADVANCED DIKETONE INTERMEDIATE - DEMONSTRATION THAT RECONSTRUCTION OF THE 8-MEMBERED RING SUFFERS FROM SERIOUS KINETIC RETARDATION [J].
PAQUETTE, LA ;
BULMANPAGE, PC ;
PANSEGRAU, PD ;
WIEDEMAN, PE .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (07) :1450-1460
[99]   A RELAY APPROACH TO (+)-PLEUROMUTILIN .2. PREPARATION OF AN ADVANCED OPTICALLY PURE INTERMEDIATE [J].
PAQUETTE, LA ;
BULMANPAGE, PC .
TETRAHEDRON LETTERS, 1985, 26 (13) :1607-1610
[100]   Antimicrobial Activity of the Pleuromutilin Antibiotic BC-3781 against Bacterial Pathogens Isolated in the SENTRY Antimicrobial Surveillance Program in 2010 [J].
Paukner, Susanne ;
Sader, Helio S. ;
Ivezic-Schoenfeld, Zrinka ;
Jones, Ronald N. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (09) :4489-4495
567891011121314