Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography

被引：6

作者：

Jolly, Dean ^{[1
]}

Hopewell, Robert ^{[1
]}

Kovacevic, Miriam ^{[1
]}

Li, Qian Ying ^{[1
]}

Soucy, Jean-Paul ^{[1
,2
]}

Kostikov, Alexey ^{[1
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

[2] Concordia Univ, Concordia PERFORM Ctr, Montreal, PQ, Canada

来源：

APPLIED RADIATION AND ISOTOPES | 2017年 / 121卷

关键词：

Positron Emission Tomography; Carbon-11; radiotracers; Automated radiolabeling; Kit-like production; IN-VIVO; RECEPTOR; RADIOLIGANDS;

D O I：

10.1016/j.apradiso.2016.11.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the technical difficulties associated with [C-11]CO2 conversion into the highly reactive methylating agents [C-11]CH3I and [C-11]CH3OTf using automated modules relying on stationary valves. Here we describe development of the first in its kind "[C-11]kit" for production of carbon-11 radiotracer using disposable manifolds. This method proved to be very reliable and allows for consecutive production of PET tracers with minimal intervals between the syntheses.

引用

页码：76 / 81

页数：6

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