Meroterpenoids from the Alga-Derived Fungi Penicillium thomii Maire and Penicillium lividum Westling

被引：44

作者：

Zhuravleva, Olesya I. ^{[1
,2
]}

Sobolevskaya, Maria P. ^{[1
]}

Leshchenko, Elena V. ^{[2
]}

Kirichuk, Natalya N. ^{[1
]}

Denisenko, Vladimir A. ^{[1
]}

Dmitrenok, Pavel S. ^{[1
]}

Dyshlovoy, Sergey A. ^{[1
,2
]}

Zakharenko, Alexander M. ^{[1
,2
]}

Kim, Natalya Yu. ^{[1
]}

Afiyatullov, Shamil Sh. ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

[2] Far Eastern Fed Univ, Vladivostok 690950, Russia

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

ASPERGILLUS-USTUS; INDUCED TRANSFORMATION; STRUCTURE ELUCIDATION; CANCER-CELLS; METABOLITES; AUSTALIDES; BIOSYNTHESIS; AP-1;

D O I：

10.1021/np500151b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new austalide meroterpenoids (1-10) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The absolute configurations of some of the metabolites were assigned by the modified Mosher's method and CD data. Compounds 1, 2, 8, and 9 were able to inhibit AP-1-dependent transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations. Austalides 1-5, 8, and 9 exhibited significant inhibitory activity against endo-1,3-beta-D-glucanase from a crystalline stalk of the marine mollusk Pseudocardium sachalinensis.

引用

页码：1390 / 1395

页数：6

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