Mean Platelet Volume and Vitamin D Level

Background: Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. Methods: This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MIN was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively. Results: The vitamin D level in Group 1 (7.7 +/- 1.9 ng/mL) was lower than that in Group 2 (15.1 +/- 1.6 ng/mL, P<0.001) and Group 3 (25.6 +/- 6.3 ng/mL, P<0.001). The MPV in Group 3 (7.5 +/- 1.0 fL) was lower than that in Group 1 (8.1 +/- 1.1 fL, P<0.001) and Group 2 (7.9 +/- 1.0 fL, P=0.009). Linear regression analysis showed that low levels of vitamin D (beta = -0.109, P = 0.019) was independently associated with increased MPV. Conclusions: There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.