New pharmacological treatment options for chronic constipation

被引：16

作者：

Corsetti, Maura ^{[1
]}

Tack, Jan ^{[1
]}

机构：

[1] Univ Leuven, Translat Res Ctr Gastrointestinal Disorders, B-3000 Louvain, Belgium

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2014年 / 15卷 / 07期

关键词：

5-HT4; chronic constipation; irritable bowel syndrome with constipation; guanylate cyclase-C; ileal bile acid transporter inhibitor; PEG; IRRITABLE-BOWEL-SYNDROME; RANDOMIZED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; ACID TRANSPORTER INHIBITOR; 5-HT4 RECEPTOR AGONISTS; DOUBLE-BLIND; COLONIC TRANSIT; ENTEROKINETIC AGENT; GASTROINTESTINAL TRANSIT; IDIOPATHIC CONSTIPATION;

D O I：

10.1517/14656566.2014.900543

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: A number of new medications were recently demonstrated to be more effective than placebo in treating chronic constipation, including the intestinal chloride channel activator lubiprostone, the prokinetic selective 5-HT4 receptor agonist prucalopride and the guanylate cyclase-C agonist linaclotide. Recent publications have also revisited traditional laxatives like PEG. Moreover, a number of pharmacological treatments are in development and these include another guanylate cyclase-C agonist, plecanatide and an ileal bile acid transporter inhibitor, elobixibat. Areas covered: This review focuses on the pharmacology, efficacy and safety profile of prucalopride, linaclotide, plecanatide and elobixibat. Expert opinion: The possible present or future clinical application of prucalopride, linaclotide, plecanatide and elobixibat in both chronic constipation and irritable bowel syndrome with constipation is reported, and some considerations on the possible role of PEG taking into account recent literature are advanced.

引用

页码：927 / 941

页数：15

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