Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds

被引:31
作者
Mohammed, A. M. [1 ]
Velazquez, L. [2 ]
Chisenhall, A. [1 ]
Schiffels, D. [2 ,5 ]
Fygenson, D. K. [2 ,3 ]
Schulman, R. [1 ,4 ]
机构
[1] Johns Hopkins Univ, Chem & Biomol Engn, Baltimore, MD 21218 USA
[2] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA
[3] Univ Calif Santa Barbara, Biomol Sci & Engn, Santa Barbara, CA 93106 USA
[4] Johns Hopkins Univ, Comp Sci, Baltimore, MD 21218 USA
[5] Nanofabricat Res Grp, Gaithersburg, MD USA
基金
美国国家科学基金会;
关键词
MITOTIC SPINDLE; PEPTIDE; NUCLEATION; ACTIN;
D O I
10.1039/c6nr06983e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We demonstrate a versatile process for assembling micron-scale filament architectures by controlling where DNA tile nanotubes nucleate on DNA origami assemblies. "Nunchucks," potential mechanical magnifiers of nanoscale dynamics consisting of two nanotubes connected by a dsDNA linker, form at yields sufficient for application and consistent with models.
引用
收藏
页码:522 / 526
页数:5
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