Sesquiterpenes from Curcuma wenyujin with their inhibitory activities on nitric oxide production in RAW 264.7 cells

被引：20

作者：

Gao, Suyu ^{[1
]}

Xia, Guiyang ^{[1
]}

Wang, Liqing ^{[1
]}

Zhou, Li ^{[1
]}

Zhao, Feng ^{[2
]}

Huang, Jian ^{[1
]}

Chen, Lixia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ,Dept Nat Prod Chem, Shenyang, Peoples R China

[2] Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ,Sch Pharm, Yantai, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 05期

关键词：

Curcuma wenyujin; essential oil; sesquiterpenoids; nitric oxide; biosynthesis pathway; GUAIANE-TYPE SESQUITERPENES; ABSOLUTE-CONFIGURATION; ZEDOARIAE RHIZOMA; DIARYLHEPTANOIDS; LONGA; PHAEOCAULIS; STEREOSTRUCTURE; KWANGSIENSIS; ALCOHOLS;

D O I：

10.1080/14786419.2016.1205053

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new sesquiterpene, 7 alpha, 11-epoxy-6 alpha-hydroxy-carabrane-4,8dione, along with 10 known ones were isolated from the essential oil of Curcuma wenyujin Y.H. Chen et C. Ling. Their structures were established based on extensive spectroscopic analysis. The absolute configuration of compound 1 was determined by the CD analysis of the insitu formed [Rh-2(OCOCF3)(4)] complex, and the CD data analysis based on the octane rule of cyclohexanone. The inhibitory effects of these sesquiterpenes on nitric oxide production in lipopolysaccharideactivated macrophages were also evaluated. Furthermore, the biosynthesis pathway of the isolated compounds was proposed.

引用

页码：548 / 554

页数：7

共 40 条

[1] Non-phenolic linear diarylheptanoids from Curcuma xanthorrhiza: A novel type of topical anti-inflammatory agents: Structure-activity relationship [J].