Nanocoating for biomolecule delivery using layer-by-layer self-assembly

被引：105

作者：

Keeney, M. ^{[1
]}

Jiang, X. Y. ^{[1
]}

Yamane, M. ^{[2
]}

Lee, M. ^{[3
]}

Goodman, S. ^{[1
]}

Yang, F. ^{[1
,3
]}

机构：

[1] Dept Orthopaed Surg, Stanford, CA 94305 USA

[2] Stanford Univ, Program Human Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 45期

基金：

美国国家科学基金会;

关键词：

MULTILAYER FILMS; POLYELECTROLYTE MULTILAYERS; DRUG-RELEASE; THIN-FILMS; TRIGGERED RELEASE; PROTEIN DELIVERY; SEQUENTIAL RELEASE; INDUCED DISRUPTION; NUCLEIC-ACIDS; DNA;

D O I：

10.1039/c5tb00450k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Since its introduction in the early 1990s, layer-by-layer (LbL) self-assembly of films has been widely used in the fields of nanoelectronics, optics, sensors, surface coatings, and controlled drug delivery. The growth of this industry is propelled by the ease of film manufacture, low cost, mild assembly conditions, precise control of coating thickness, and versatility of coating materials. Despite the wealth of research on LbL for biomolecule delivery, clinical translation has been limited and slow. This review provides an overview of methods and mechanisms of loading biomolecules within LbL films and achieving controlled release. In particular, this review highlights recent advances in the development of LbL coatings for the delivery of different types of biomolecules including proteins, polypeptides, DNA, particles and viruses. To address the need for co-delivery of multiple types of biomolecules at different timing, we also review recent advances in incorporating compartmentalization into LbL assembly. Existing obstacles to clinical translation of LbL technologies and enabling technologies for future directions are also discussed.

引用

页码：8757 / 8770

页数：14

共 113 条

[1] Mechanisms of controlled drug release from drug-eluting stents [J].