Targeting DNA Repair Pathways in Hematological Malignancies

被引：13
作者：
Alhmoud, Jehad F. [1 ]
Mustafa, Ayman G. [2 ]
Malki, Mohammed Imad [2 ]
机构：
[1] Al Ahliyya Amman Univ, Fac Appl Med Sci, Dept Med Lab Sci, Amman 19328, Jordan
[2] Qatar Univ, QU Hlth, Coll Med, POB 2713, Doha, Qatar
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 19期
关键词：
DNA repair; DNA damage; hematological malignancies; apoptosis; mutation; ACUTE MYELOID-LEUKEMIA; MANTLE CELL LYMPHOMA; DOUBLE-STRAND BREAKS; ACUTE LYMPHOBLASTIC-LEUKEMIA; DAMAGE RESPONSE; ATAXIA-TELANGIECTASIA; SYNTHETIC LETHALITY; GENOMIC INSTABILITY; EPIGENETIC THERAPY; INHIBITOR MK-8776;
D O I：
10.3390/ijms21197365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple genomic changes that ultimately may result in mutation, tumor growth, and/or cell apoptosis. Furthermore, impaired repair mechanisms can also lead to genomic instability, which can initiate tumorigenesis and development of hematological malignancy. This review discusses recent findings and highlights the importance of DNA repair components and the impact of their aberrations on hematological malignancies.
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页码：1 / 17
页数：17
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