Stem Cell-Based Therapies for Spinal Cord Injury

被引：111

作者：

Tewarie, Rishi S. Nandoe ^{[1
,2
]}

Hurtado, Andres ^{[2
]}

Bartels, Ronald H. ^{[1
]}

Grotenhuis, Andre ^{[1
]}

Oudega, Martin ^{[2
,3
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Neurosurg, NL-6500 HB Nijmegen, Netherlands

[2] Hugo W Moser Res Inst Kennedy Krieger, Int Ctr Spinal Cord Injury, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

JOURNAL OF SPINAL CORD MEDICINE | 2009年 / 32卷 / 02期

关键词：

Spinal cord injuries; Stem cells; Totipotency; Pluripotency; Cell transplantation; Neuroprotection; Axon regeneration; Gene therapy; Ethics; MARROW STROMAL CELLS; NEURAL PROGENITOR CELLS; CENTRAL-NERVOUS-SYSTEM; BONE-MARROW; FUNCTIONAL RECOVERY; IN-VIVO; STEM/PROGENITOR CELLS; GROWTH-FACTORS; SCHWANN-CELL; RAT-BRAIN;

D O I：

10.1080/10790268.2009.11760761

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spinal cord injury (SCI) results in loss of nervous tissue and consequently loss of motor and sensory function. There is no treatment available that restores the injury-induced loss of function to a degree that an independent life can be guaranteed. Transplantation of stem cells or progenitors may support spinal cord repair. Stem cells are characterized by self-renewal and their ability to become any cell in an organism. Promising results have been obtained in experimental models of SCI. Stem cells can be directed to differentiate into neurons or glia in vitro, which can be used for replacement of neural cells lost after SCI. Neuroprotective and axon regeneration-promoting effects have also been credited to transplanted stem cells. There are still issues related to stem cell transplantation that need to be resolved, including ethical concerns. This paper reviews the current status of stem cell application for spinal cord repair.

引用

页码：105 / 114

页数：10

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