The effect of short-duration bursts of high-frequency, low-intensity transcranial magnetic stimulation on the human motor cortex

被引:136
作者
Huang, YZ [1 ]
Rothwell, JC [1 ]
机构
[1] UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England
关键词
repetitive transcranial magnetic stimulation; theta burst stimulation; motor evoked potential; intracortical inhibition;
D O I
10.1016/j.clinph.2003.12.026
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To explore the effect of applying a short burst of high-frequency repetitive transcranial magnetic stimulation (rTMS) to the human motor cortex as a preparatory investigation before attempting theta burst stimulation in humans. Methods: Five or 15 pulses of 50 Hz rTMS were given at 50-80% active motor threshold (AMT). The time course of changes in motor-evoked potential (MEP) size and short interval intracortical inhibition (SICI) were evaluated from 20 to 300 ms after the end of each burst in the relaxed first dorsal interosseous muscle of 15 healthy volunteers. Results: No subjects noted any adverse effects. MEPs were enhanced and SICIs were reduced at 20 ms after a burst of either 5 or 15 pulses at 70 or 80% AMT, but not at 50% AMT. Subsequent experiments used a 5 pulse burst at 80% AMT. The threshold for producing SICI increased from 60 to 80% AMT when tested 10 or 20 ms after the end of the burst. MEPs were enhanced for 100 ms, whereas SICI was reduced for 200-300 ms. Conclusions: A short burst of low-intensity 50 Hz rTMS over the hand motor area transiently increases MEP amplitude with a longer lasting decrease in SICI. Significance: This means that it may be possible in future experiments to apply theta burst conditioning safety to the human cortex. (C) 2004 Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology.
引用
收藏
页码:1069 / 1075
页数:7
相关论文
共 25 条
[1]   Facilitation of muscle evoked responses after repetitive cortical stimulation in man [J].
Berardelli, A ;
Inghilleri, M ;
Rothwell, JC ;
Romeo, S ;
Currà, A ;
Gilio, F ;
Modugno, N ;
Manfredi, M .
EXPERIMENTAL BRAIN RESEARCH, 1998, 122 (01) :79-84
[2]  
BESTMAN S, 2004, IN PRESS CLIN NEUROP
[3]   Intracortical inhibition and facilitation in different representations of the human motor cortex [J].
Chen, R ;
Tam, A ;
Bütefisch, C ;
Corwell, B ;
Ziemann, U ;
Rothwell, JC ;
Cohen, LG .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (06) :2870-2881
[4]   Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].
Chen, R ;
Classen, J ;
Gerloff, C ;
Celnik, P ;
Wassermann, EM ;
Hallett, M ;
Cohen, LG .
NEUROLOGY, 1997, 48 (05) :1398-1403
[5]   Transcranial magnetic stimulation: A new investigational and treatment tool in psychiatry [J].
Daskalakis, ZJ ;
Christensen, BK ;
Fitzgerald, PB ;
Chen, R .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2002, 14 (04) :406-415
[6]   Therapeutic efficacy of bilateral prefrontal slow repetitive transcranial magnetic stimulation in depressed patients with Parkinson's disease: An open study [J].
Dragasevic, N ;
Potrebic, A ;
Damjanovic, A ;
Stefanova, E ;
Kostic, VS .
MOVEMENT DISORDERS, 2002, 17 (03) :528-532
[7]   Decreased corticospinal excitability after subthreshold 1 Hz rTMS over lateral premotor cortex [J].
Gerschlager, W ;
Siebner, HR ;
Rothwell, JC .
NEUROLOGY, 2001, 57 (03) :449-455
[8]   Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease:: Implications for the pathophysiology of cortical function [J].
Gilio, F ;
Currà, A ;
Inghilleri, M ;
Lorenzano, C ;
Manfredi, M ;
Berardelli, A .
MOVEMENT DISORDERS, 2002, 17 (03) :467-473
[9]   Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex [J].
Hess, G ;
Aizenman, CD ;
Donoghue, JP .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) :1765-1778
[10]   The effect of current direction induced by transcranial magnetic stimulation on the corticospinal excitability in human brain [J].
Kaneko, K ;
Kawai, S ;
Fuchigami, Y ;
Morita, H ;
Ofuji, A .
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1996, 101 (06) :478-482