Optimal management of metastatic castration-resistant prostate cancer: Highlights from a European Expert Consensus Panel

被引：123

作者：

Fitzpatrick, John M. ^{[1
,2
]}

Bellmunt, Joaquim ^{[3
]}

Fizazi, Karim ^{[4
]}

Heidenreich, Axel ^{[5
]}

Sternberg, Cora N. ^{[6
]}

Tombal, Bertrand ^{[7
,8
]}

Alcaraz, Antonio ^{[9
]}

Bahl, Amit ^{[10
]}

Bracarda, Sergio ^{[11
]}

Di Lorenzo, Giuseppe ^{[12
]}

Efstathiou, Eleni ^{[13
]}

Finn, Stephen P. ^{[14
,15
]}

Fossa, Sophie ^{[16
]}

Gillessen, Silke ^{[17
]}

Kellokumpu-Lehtinen, Pirkko-Liisa ^{[18
]}

Lecouvet, Frederic E. ^{[7
,8
]}

Oudard, Stephane ^{[19
]}

de Reijke, Theo M. ^{[20
]}

Robson, Craig N. ^{[21
]}

De Santis, Maria ^{[22
]}

Seruga, Bostjan ^{[23
]}

de Wit, Ronald ^{[24
]}

机构：

[1] Irish Canc Soc, Dublin, Ireland

[2] Univ Coll Dublin, Dublin 2, Ireland

[3] Univ Hosp del Mar, Barcelona, Spain

[4] Univ Paris 11, Inst Gustave Roussy, Villejuif, France

[5] Univ Hosp Aachen, Aachen, Germany

[6] San Camillo & Forlanini Hosp, Rome, Italy

[7] Clin Univ St Luc, Ctr Canc, B-1200 Brussels, Belgium

[8] Clin Univ St Luc, IREC, B-1200 Brussels, Belgium

[9] Hosp Clin Barcelona, Barcelona, Spain

[10] Univ Hosp Bristol, Bristol, Avon, England

[11] Osped San Donato, ITT, Arezzo, Italy

[12] Univ Naples Federico II, Naples, Italy

[13] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[14] St James Hosp, Dublin 8, Ireland

[15] Trinity Coll Dublin, Dublin, Ireland

[16] Norwegian Radium Hosp, Oslo Univ Hosp, Oslo, Norway

[17] Kantonsspital St Gallen, St Gallen, Switzerland

[18] Tampere Univ Hosp, Tampere, Finland

[19] Georges Pompidou European Hosp, Paris, France

[20] Univ Amsterdam, Acad Med Ctr, Dept Urol, NL-1105 AZ Amsterdam, Netherlands

[21] Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[22] Kaiser Franz Josef Spital, Ludwig Boltzmann Inst Appl Canc Res, Vienna, Austria

[23] Inst Oncol Ljubljana, Dept Med Oncol, Ljubljana, Slovenia

[24] Erasmus Univ, Med Ctr, Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF CANCER | 2014年 / 50卷 / 09期

关键词：

Metastatic castration-resistant prostate cancer; Consensus; Radium; 223; dichloride; Abiraterone; Enzalutamide; Docetaxel; Circulating tumour cells; Sipuleucel-T; Cabazitaxel; Denosumab; ABIRATERONE ACETATE; ANTITUMOR-ACTIVITY; INCREASED SURVIVAL; AXIAL SKELETON; DOCETAXEL; ENZALUTAMIDE; MEN; CHEMOTHERAPY; MITOXANTRONE; PREDNISONE;

D O I：

10.1016/j.ejca.2014.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The exponential growth of novel therapies for the treatment of metastatic castration-resistant prostate cancer (mCRPC) over the last decade has created an acute need for education and guidance of clinicians regarding optimal strategies for patient management. A multidisciplinary panel of 21 European experts in mCRPC assembled for comprehensive discussion and consensus development, seeking to move the field forward and provide guidance and perspectives on optimal selection and sequencing of therapeutic agents and monitoring of response to treatment and disease progression. A total of 110 clinically-relevant questions were addressed and a modified Delphi method was utilised to obtain a consensus. The panel reached a consensus on several important issues, providing recommendations on appropriate phase III clinical trial end-points and optimal strategies for imaging and monitoring of bone metastases. Guidance regarding selection and sequencing of therapy in patients with newly diagnosed or progressive mCRPC is emphasised, including the use of novel bone-targeted agents, chemotherapy, androgen receptor pathway-targeted agents and immunotherapy. The impact of drug resistance and prostate-specific antigen flare on treatment decisions was also addressed. Ultimately, individualised therapy for patients with mCRPC is dependent on continued refinement of clinical decision-making based on patient and disease characteristics. This consensus statement offers clinicians expert guidance on the implementation of recent advances to improve patient outcome, focusing on the future of prostate cancer care. (C) 2014 The Authors. Published by Elsevier Ltd.

引用

页码：1617 / 1627

页数：11

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