Pulmonary macrophages: key players in the innate defence of the airways

被引：386

作者：

Byrne, Adam J. ^{[1
]}

Mathie, Sara A. ^{[1
]}

Gregory, Lisa G. ^{[1
]}

Lloyd, Clare M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Leukocyte Biol Sect, London SW7 2AZ, England

来源：

THORAX | 2015年 / 70卷 / 12期

基金：

英国惠康基金;

关键词：

ALTERNATIVELY ACTIVATED MACROPHAGES; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; ALVEOLAR MACROPHAGES; LUNG INJURY; MYELOID CELLS; FIBROSIS; EXPRESSION; RESPONSES; INFLAMMATION;

D O I：

10.1136/thoraxjnl-2015-207020

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Macrophages are the most numerous immune-cells present in the lung environment under homoeostatic conditions and are ideally positioned to dictate the innate defence of the airways. Pulmonary macrophage populations are heterogeneous and demonstrate remarkable plasticity, owing to variations in origin, tissue residency and environmental influences. Lung macrophage diversity facilitates considerable specialisation, aids efficient responses to environmental signals and allows rapid alterations in phenotype and physiology in response to a plethora of cytokines and microbial signals. This review describes pulmonary macrophage origins, phenotypes, roles in diseases of the airways and implications for the treatment of respiratory disease.

引用

页码：1189 / 1196

页数：8

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