Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

被引：38

作者：

Christensen, Alexander Sidelmann ^{[1
]}

Moller, Jonas Bech ^{[2
]}

Hasselbalch, Hans Carl ^{[1
]}

机构：

[1] Univ Copenhagen, Roskilde Hosp, Dept Hematol, Roskilde, Denmark

[2] Novo Nordisk AS, Quantitat Clin Pharmacol, Soborg, Denmark

来源：

LEUKEMIA RESEARCH | 2014年 / 38卷 / 04期

关键词：

Myeloproliferative neoplasms; Essential thrombocythemia; Polycythemia vera; Myelofibrosis; Chronic kidney disease; Chronic inflammation; Hydroxyurea; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; POLYCYTHEMIA-VERA; ESSENTIAL THROMBOCYTHEMIA; CHRONIC INFLAMMATION; PREVALENCE; THROMBOSIS; DISORDERS; CYTOKINES; MORTALITY; SCLEROSIS;

D O I：

10.1016/j.leukres.2014.01.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality. Methods: This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years. Results: 29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3 mL/min/1.73 m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts. Conclusion: Kidney impairment might contribute to the increased mortality observed in MPN patients. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：490 / 495

页数：6

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