Subcellular location of astrocytic calcium stores favors extrasynaptic neuron-astrocyte communication

被引：90

作者：

Patrushev, Ilya ^{[2
]}

Gavrilov, Nikolay ^{[3
]}

Turlapov, Vadim ^{[3
]}

Semyanov, Alexey ^{[1
,2
,3
]}

机构：

[1] RIKEN, BSI, Wako, Saitama 3510198, Japan

[2] RIKEN, BSI, Wako, Saitama 3510198, Japan

[3] Univ Nizhny Novgorod, Nizhnii Novgorod, Russia

来源：

CELL CALCIUM | 2013年 / 54卷 / 05期

关键词：

Astrocyte; Postsynaptic density; Perisynaptic processes; Neuron-glia interaction; SYNAPSE FORMATION; GLUTAMATE; CA2+; RELEASE; GLIA; OSCILLATIONS; HIPPOCAMPUS; PLASTICITY; RECEPTORS; ASTROGLIA;

D O I：

10.1016/j.ceca.2013.08.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neuron-astrocyte interactions are important for brain computations and synaptic plasticity. Perisynaptic astrocytic processes (PAPs) contain a high density of transporters that are responsible for neurotransmitter clearance. Metabotropic glutamate receptors are thought to trigger Ca2+ release from Ca2+ stores in PAPs in response to synaptic activity. Our ultrastructural study revealed that PAPs are actually devoid of Ca2+ stores and have a high surface-to-volume ratio favorable for uptake. Astrocytic processes containing Ca2+ stores were located further away from the synapses and could therefore respond to changes in ambient glutamate. Thus, the anatomic data do not support communication involving Ca2+ stores in tripartite synapses, but rather point to extrasynaptic communication. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：343 / 349

页数：7

共 44 条

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